AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |
Back to Blog
Level 14 brain test 2 agent smith12/24/2023 Since the discovery of the meningeal lymphatics in 2015 1, 2, the interstitial fluid (ISF)-cerebrospinal fluid (CSF)-meningeal lymphatic drainage pathway has been considered the major route for brain and spinal cord waste disposal. Cu-albumin PET revealed the age-related decrease of the lymphatic drainage of CSF due to this decreased drainage from the subarachnoid space, especially during the stationary phase, in aged mice. Cu-albumin PET enabled us to quantify CSF-lymphatic drainage across all levels of brain spinal cords and to visualize and quantify lymph node activity due to CSF drainage. While the % injected dose of CSF space were higher, the activity of the paravertebral lymph nodes were lower in the aged mice on the next day. Stationary phase of the next day followed the initial perturbed state by injection of 6 ul (1/7 of total CSF volume) and CSF clearance half-time from the subarachnoid space was 93.4 ± 19.7 and 123.3 ± 15.6 min in adult and aged mice (p = 0.01), respectively. CSF clearance and paravertebral lymph nodes were quantified after injection and during the stationary phase. Cu-albumin PET was performed at multiple time points after intrathecal injection of Cu-albumin at an infusion rate of 700 nl/min in adult and aged mice (15–25 months old). In this study, intrathecal Cu-albumin positron emission tomography (PET) was applied in mice to evaluate lymphatic drainage of CSF and its variation with age. Age-related cognitive decline is associated with dysfunctional lymphatic drainage of cerebrospinal fluid (CSF) through meningeal lymphatic vessels.
0 Comments
Read More
Leave a Reply. |